At MSD, we have and always will be…Inventing for Life. These three powerful words reflect our commitment to inventing new medicines and vaccines that save lives by preventing and fighting disease. MSD has dedicated researchers trained in many different scientific disciplines who work tirelessly to find cures for significant diseases that still afflict millions around the world and we will continue on this path. We offer employees hugely ambitious and exciting career paths, working at the cutting edge of science and technology, creating new treatments and products that save and enhance lives, playing a significant role in addressing the world’s most vital, unmet needs.
At MSD Ireland we firmly believe that the most important thing we make is a difference – to patients, to our employees, to our communities and to the Irish healthcare landscape generally. MSD Ireland is 100% committed to putting the patient at the heart of everything we do and we are also firmly focused on giving back to the communities that we operate in and bringing real value to the Irish healthcare landscape generally. Over the last five years we have consistently been ranked as one of the top five business contributors in Ireland and over that period our employees have volunteered over 1400 hours to a host of projects. In fact, our employees have helped and supported over 500 local projects and have contributed over €5.8 million to a range of worthy causes and projects.
To learn more about MSD, our operations in Ireland and the career opportunities available, please visit www.msd.ie
Qualitative methods determine precisely what substances are present in a product. Quantitative methods assess the concentration of the active ingredient. It is not enough to rely solely on testing to maintain the quality of a product, i.e. ‘quality by testing’. Today ‘Quality by Design’ is a key feature of the pharmaceutical industry.
Many manufacturing processes produce items that vary slightly in some way (dimensions, mass, resistance etc.) but are generally within certain limits. Repeated physical measurements of sample items tend to follow what is called a normal distribution about the average or mean value. Variations can be due to the manufacturing processes or the measurement process.
In the production of chemical substances, especially pharmaceuticals, it is important to ensure that the products are pure and uncontaminated. Separation techniques are the methods used to remove one substance from a mixture containing any number of other substances, for harvesting or identification.
Monoclonal antibodies are artificially produced antibodies designed to target and bind to specific antigens. They are use to treat specific conditions such as: arthritis, asthma, B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, Crohn’s disease, dermatitis, melanoma, multiple sclerosis, psoriasis and many more.
The innate immune system is always ready to fight infection while the adaptive (or ‘specific’) immune system is activated when the innate system fails to stop infection. Inflammatory disease can be caused by an autoimmune response in which the body’s immune system attacks normal healthy tissue mistaking it for a pathogen.
Interferon inhibits cell proliferation and so has anti-cancer properties. In order to make it DNA coding for interferon is introduced into E. coli bacteria which multiply and produce commercial quantities of interferon. The cells are regularly harvested and the interferon extracted. Genetic modification of the bacteria is necessary as otherwise they would destroy the interferon, a protein foreign to them.